These are keys I use for ZSNES, so you may want to use them yourself (otherwise you would have to change the game profile itself, which is much more time-consuming):
Up:E
Down:D
Left:S
Right:F
Start:Enter
Select:rShift
A:I
B:J
X:L
Y:K
L:U
R:O
Rewind:F11
Fast forward: ''
Pause game:F7
Load:F12
Save:F10
Pick:F9
+Vol:F6
-Vol:F5
Clock:Tab
Make sure 'Misc -> GUI options -> GUI switches ->Esc to game menu' is on for the 'Pick' configuration to work properly.
This profile consists of three configurations; Player 1, Pick and Menu. How they are linked thogether is quite complicated, but after you've learned how it's done, it's pretty easy.
NOTE: What's in blue/indigo indicates what the certain buttons do while the SHIFT BUTTON is being held. The functions of the buttons gets back to normal when SHIFT BUTTON is released.
Menu
Up:Arrow UP
Down:Arrow DOWN
Left:Arrow LEFT
Right:Arrow RIGHT
Button 1:Enter
Button 2:Escape
Button A:Tab
Home:'Player 1'
Button B:SHIFT BUTTON
Up:Mouse move UP
Down:Mouse move DOWN
Left:Mouse move LEFT
Right:Mouse move RIGHT
Button 1:Mouse button LEFT
So here you'll have to press Home when ready to play.
Player 1
Up:Up(E)
Down:Down(D)
Left:Left(S)
Right:Right(F)
Plus:Start(Enter)
Minus:Select(rShift)
Button 1:Y(K)
Button 2:B(J)
Button A:X(L)
Home:A(I)
Tiltsensor:L, R(U, O)
Button B:SHIFT BUTTON
Button 1:Rewind(F11)
Button 2:Fast forward(')
Left:Pause game(F7)
Plus:Load(F12)
Minus:Save(F10)
Home:'Pick'(F9)
Up:+Vol(F6)
Down:-Vol(F5)
Right:Clock(Tab)
Button A: Moves the SHIFT BUTTON function from Button B to Button A(release B and A after pressed to make this change happen)
Home:X(was control A)
Button B:A(was SHIFT BUTTON)
Button A:SHIFT BUTTON(was control X)
Button B: Moves the SHIFT BUTTON function from Button A to Button B
When direction pads, Button 1 and Button 2 are used simultaneous, and you want to use the function of Home at the same time being possible, press Button B followed by Button A to move this function from Home to Button B (this is when Button B is the SHIFT BUTTON). Press Button A followed by Button B to switch back to normal (when Button A is the SHIFT BUTTON).
Button B + Home = 'Pick'(B as SHIFT BUTTON)
Button A + Home = 'Pick'(A as SHIFT BUTTON)
Pick
Left:Arrow LEFT
Right:Arrow RIGHT
Button 1:Enter+'Player 1'
Button 2:Escape(x2)+'Menu'
If you want the menu press Button 2, and then again off course you'll need to press Home, if you want to play more, but if you're not finished with menu and press Home, you'll neither have 'Enter' nor 'Escape' to your controller no longer and will therefore get stuck in menu. A solution to that problem is solved by pressing Button B(SHIFT BUTTON)+Home followed by Button 2, and you're back to Menu.